The Healthy Gut Podcast Ep.64
Hydrogen Sulphide SIBO
Mark Pimentel, M.D., is Professor of Medicine, Geffen School of Medicine and Associate Professor at Cedars-Sinai Medical Center in Los Angeles, California. Rebecca joined him live at Cedars-Sinai in Los Angeles to speak to him about his research into Hydrogen Sulphide SIBO.
In Today's Episode
In Episode 64 of The Healthy Gut podcast, we discuss:
✓ The difference between IBS & SIBO, and what comes first? IBS or SIBO?
✓ What is Hydrogen Sulphide SIBO and how is it different from Hydrogen and Methane SIBO?
✓ How do you test for Hydrogen Sulphide SIBO? When will it be available and where?
✓ Why a traditional SIBO breath test would show a flatline result if a patient has Hydrogen Sulphide SIBO?
✓ Why Hydrogen can look falsely negative when Hydrogen Sulphide or Methane is present?
✓ Why Hydrogen takes 60 minutes to be produced and longer for Methane
✓ Why Hydrogen is not a reliable gas on SIBO breath tests
✓ Should patients be asking for Hydrogen and Methane breath tests?
✓ Why some people have a high baseline reading – how does this happen?
✓ What the methanogens are (ie. M. Smithi)? And what produces Hydrogen and Hydrogen Sulphide?
✓ Why and how methane slows intestinal transit time?
✓ If methane SIBO is more likely to cause weight gain, does that mean Hydrogen SIBO is more likely to cause weight loss? What does it mean for Hydrogen Sulphide SIBO regarding weight?
✓ How do you clinically handle the SIBO patient who has lost significant amounts of weight and can’t regain it? What’s your advice for SIBO patients who are gaining unwanted weight?
✓ Can you have 1, 2 or 3 of the gases present at the same time? If so, what’s the correlation between the gasses?
✓ What are the symptoms of Hydrogen Sulphide SIBO in comparison to the other types of SIBO? And how do the symptoms change depending on the presence of the other gases?
✓ What are the treatments for Hydrogen Sulphide SIBO? Are there any treatments/supplements Hydrogen Sulphide SIBO patients should avoid?
✓ Does the diet need to be modified any differently for Hydrogen Sulphide SIBO than the commonly used SIBO diets?
✓ Should we be staying on a low FODMAP/SIBO diet long term? What are the risks if we do?
✓ What do you see clinically works for your patients who don’t respond to traditional SIBO treatments (potentially multiple rounds of all currently available treatment options)?
✓ How important is it for us to identify the underlying cause(s) of SIBO? What should a patient do if they can’t identify an underlying cause?
✓ How can we test our MMC and transit time? How important is it to know this?
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Connect with Dr Mark Pimentel
Mark Pimentel, M.D., is Professor of Medicine, Geffen School of Medicine and Associate Professor at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Pimentel completed 3 years of an undergraduate degree in honors microbiology and biochemistry at the University of Manitoba,Canada. This was followed by his medical degree, and his BSc (Med) from the University of Manitoba Health Sciences Center in Winnipeg, Manitoba, Canada, where he also completed a residency in internal medicine. His medical training includes a fellowship in gastroenterology at the UCLA Affiliated Training Program.
Active in research, Dr. Pimentel has served as a principal investigator or co-investigator for numerous basic science, translational and clinical studies in such areas as IBS, and the relationship between gut flora composition and human disease. His work has been published in the New England Journal of Medicine, Annals of Internal Medicine, American Journal of Physiology, American Journal of Medicine, American Journal of Gastroenterology and Digestive Diseases and Sciences, among others.
Dr. Pimentel has been invited to present his work at meetings, grand rounds, and advisory boards in the United States and Internationally. He is diplomate of the American Board of Internal Medicine (Gastroenterology) and a fellow of the Royal College of Physicians and Surgeons of Canada. Dr. Pimentel is also a member of several medical associations including the American Gastroenterological Association, the American College of Gastroenterology, and the American Neurogastroenterology and Motility Society.
A few of Dr. Pimentel’s most significant accomplishments include:
1. The discovery of rifaximin as a treatment for irritable bowel syndrome (IBS)
2. He developed the first blood test for IBS on the basis of IBS being derived from acute gastroenteritis
3. Described the association between IBS and bacterial overgrowth which forms the basis for microbiome therapies in this condition
4. Uncovered the methanogen (M. smithii) as an agent for causing constipation in humans.
5. Discovered the use of lovastatin as a microbiome treatment for constipation on the basis of inhibiting methane production by metha nogens
SIBO Patient Research Program
Would you like to participate in the forthcoming SIBO Patient Research Program? Rebecca Coomes is conducting a global research program on the SIBO patient. This research will be presented to doctors, other researchers and health practitioners so they can better understand who the SIBO patient is and how they can treat them effectively.
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About The Host
Rebecca Coomes is an author, entrepreneur, passionate foodie and intrepid traveller. She transformed her health after a lifetime of chronic illness, and today guides others on their own path to wellness. She is the founder of The Healthy Gut, a platform where people can learn about gut health and how it is important for a healthy mind and body and coaches people on how to live well with SIBO. Rebecca is the author of the world’s first cookbooks for people treating Small Intestinal Bacterial Overgrowth (SIBO) and the host of the SIBO cooking show and The Healthy Gut podcast.